FIGURE

Fig 5

ID

ZDB-FIG-251030-64

Publication

Goering et al., 2025 - Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism

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Fig 5

Model of the mechanism of action of 3-HK improving macrophage function during in vivo infection.

3-HK, given exogenously or produced endogenously in the kynurenine pathway by Kmo, antagonizes kainate receptors to reduce the intracellular burden of S. Typhimurium in macrophages through enhanced lysosomal acidification. Schematic created with BioRender [25].

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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