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Locomotor and stereotypic behavioral analysis in WT and ube3a mutants. (a) Representative locomotor traces for WT and mutant fish in the open-field test. (b) Average distance traveled by WT (N = 18) and mutants (N = 18), representative traces (left) and quantification (right). (c) Stereotypic movements in adult WT (N = 13) and mutants (N = 12) with schematic representation and quantification: back-and-forth swimming (top left), figure eight-like patterns (top right), small circling (bottom left), and walling behavior (bottom right). The data are presented as the mean ± SEM. ns: non-significant, **P < 0.01.
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