FIGURE

Fig. 6

ID

ZDB-FIG-251016-84

Publication

Guerra et al., 2025 - Brain accumulation of lactosylceramide characterizes GALC deficiency in a zebrafish model of Krabbe disease

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Fig. 6

Expression of enzymes involved in LacCer/cer metabolism in the brain of galcb knockout zebrafish. (A) Schematic representation of major metabolic pathways involved in LacCer/Cer metabolism. (B) The expression of the indicated genes has been assessed by RT-qPCR in the brain of wild-type (WT) and galcb knockout (KO) mutants at 4 months post fertilization. For each gene, the data were normalized to its expression in one WT animal. Data are the mean ± standard deviation of 4–6 animals per group. One-way ANOVA (Tukey's multiple comparison test): *P < 0.05, **P < 0.01, ***P < 0.001. In A, enzymes exhibiting upregulated gene expression in brains of galcb KO animals are marked by asterisks. LacCer = lactosylceramide; RT-qPCR = reverse transcriptase-quantitative PCR.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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