FIGURE

Fig. 7

ID

ZDB-FIG-250927-20

Publication

Wang et al., 2025 - Mechanically activated snai1b coordinates the initiation of myocardial delamination for trabeculation

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Fig. 7

snai1b pathways in CMs vs. epicardial and valvular cells.

a–d Abundant col1a2 mRNA colocalized with snai1b mRNA in epicardial, valvular cells (red arrowheads), and bulbus smooth muscle cells (empty red arrowheads). However, col1a2 expression was not observed in snai1b⁺ CMs (white arrowheads) of control (a), ISO-treated (b), and CRISPRa-injected (d) hearts at 4 dpf. Number of hearts: Control = 10, ISO = 6, CRISPRa (VPR) = 10. e–h At 3 dpf, LY364947, a TGF-β signaling inhibitor, attenuated trabeculation (white outlines), but the expression of snai1b (arrowheads) within BV annulus and trabecular CMs persisted. Number of hearts: Control n = 10, LY364947 n = 12. BA bulbus arteriosus, V ventricle, BV bulbus-ventricular annulus, A atrium, Ch chest wall, Myo myocardium, AV atrioventricular canal.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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