FIGURE

Fig. 2

ID

ZDB-FIG-250919-9

Publication

Hark et al., 2025 - AI-assisted phenotyping in a zebrafish hypophosphatasia model enables early and precise detection of skeletal alterations

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Fig. 2

Generation and investigation of transgenic alpl knockout zebrafish line. (A) Schematic drawing of the genomic region on chromosome 11 deleted in alpl^wue7 zebrafish larvae. The inserted alpl promoter deletion is including the alpl promoter region, together with exon 1 and parts of 5’UTR and intron 1. (B) Bone and cartilage double-stainings of 120 hpf transgenic zebrafish larvae display slightly changed craniofacial development in the neurocranium and viscerocranium. Bone (red) and cartilage (blue). Two individuals representing the same genotype, but different phenotype severities are shown for hetero- and homozygotes. wildtype = alpl^+/+; heterozygous = alpl^wue7/+; homozygous = alpl^wue7/wue7.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	alpl^wue7/wue7 (AB)
Observed In:	neurocranium neurocranium bone mineralization splanchnocranium splanchnocranium bone mineralization
Stage:	Day 5

Phenotype Detail

Acknowledgments

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