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Fig. 3

ID

ZDB-FIG-250822-30

Publication

Zhang et al., 2025 - Deep learning enhanced deciphering of brain activity maps for discovery of therapeutics for brain disorders

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Fig. 3

Consensus clustering reveals the functional diversity of the drugs (A) Data augmentation by combination-permutation strategy to compute the ten T-score BAMs for one drug. (B) The 5-dimensional pheno-prints (featured by the top 5 principal components) for ten DeepBAM clusters. (C) Consensus clustering identified ten phenotypic DeepBAM clusters. The heatmap was the consensus matrix illustrating the frequency of the scenario in which two compounds in a pair were clustered together. The color of the heatmap is proportional to the frequency scores of the consensus matrix, ranging from 0 to 1. (D) The representative cluster patterns were derived by taking the mean of all T-score BAMs for drugs in the ten clusters.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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