FIGURE

Figure 4—figure supplement 1.

ID

ZDB-FIG-250804-60

Publication

Eggeler et al., 2025 - Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry

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Figure 4—figure supplement 1.

<italic toggle='yes'>Metrns</italic> loss-of-function leads to DFC disorganization and migration defects.

(A) Sox32 antisense riboprobe in situ hybridization revealing DFC misclustering in 9 hpf metrn^-/- and metrnla^-/- embryos. (B) Quantification in percentage of the number of embryos with DFC clustering defects at 9 hpf in wild type (WT) and several metrns mutant backgrounds (Fisher exact test, ***p-value: 1.5e-05 for metrn^-/- vs. metrn⁺^/-; ***p-value: 2.5e-26 for metrnla^-/- vs. metrnla⁺^/-; ***p-value: 1.2e-13 for metrn^-/- x metrnla^-/- vs. metrn⁺^/- +/- metrnla⁺^/-; ***p-value: 2.2e-18 for triplMut vs. ♀WT x ♂triplMut and ***p-value: 2.1e-13 for triplMut vs. ♀triplMut x ♂WT). Error bars indicate standard deviation. (C) tbxta and sox17 DFC specification markers are expressed in the absence of Metrn proteins, as shown by in situ hybridization on WT and triplMut at 8 and 10 dpf, respectively. Scale bars: in (A and C) 0.5 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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