FIGURE
Fig. 4
- ID
- ZDB-FIG-250724-57
- Publication
- Liu et al., 2025 - Identification and functional analysis of a novel TBC1D23 pathogenic variant in a Chinese family with pontocerebellar hypoplasia
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Fig. 4
In silico prediction of degradation motifs in TBC1D23. (A) PEST-find analysis predicts two high-confidence PEST sequences (boxed, scores > + 5.00) in the C-terminal region of TBC1D23. (B) GPS-Uber analysis identifies eleven potential ubiquitination sites (Score > 0.2655), ten of which are located C-terminal to the truncation site. Both analyses indicate that the p.F171Qfs*8 truncation results in the loss of key degradation signals |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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