FIGURE

Fig. 4

ID

ZDB-FIG-250603-52

Publication

Grzymala et al., 2025 - Metabolomic and lipidomic profiling reveals convergent pathways in attention deficit hyperactivity disorder therapeutics: Insights from established and emerging treatments

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Fig. 4

The effect of novel treatment amlodipine on the whole-body metabolome of adgrl3.1 mutant larvae. Volcano plot of identified (A) metabolites and (B) lipids. Blue dots indicate significant downregulation, red dots significant upregulation, and gray dots nonsignificant changes. Comparison between amlodipine-treated and untreated adgrl3.1 mutant larvae revealed (A) 1 downregulated metabolite and (B) 1 downregulated lipid. Each group consisted of 3 biological replicates, with 50 pooled larvae per replicate. Differential metabolites were identified through an FC of ≥1.2 or ≤0.83 and an FDR-adjusted P value of ≤.05. Significantly altered lipids were identified through an FC of ≥1 or ≤0.5 and an FDR-adjusted P value of ≤.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Pharmacol. Exp. Ther.