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Fig. 8

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ZDB-FIG-250506-39

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Maciag et al., 2025 - Exploring the impact of MDMA and oxytocin ligands on anxiety and social responses: A comprehensive behavioural and molecular study in the zebrafish model

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Fig. 8

MDMA suppresses AKT phosphorylation. Next, we determined whether the AKT or ERK1/2 signalling pathways played a role in the behavioural effects of MDMA. Following the behavioural tests, the fish were euthanised, and protein levels were normalised before utilising the western blotting technique (a). The results indicate that a dose of 0.5??M of MDMA decreased AKT phosphorylation (b), while neither of the tested doses had an impact on ERK1/2 phosphorylation (c). Data were analysed using a t-test (b: 0.5, 1.0??M, c: 0.5, 1.0??M). Mann?Whitney test was used for datasets that failed normality testing or had significantly different variances (b: 2.5??M, c: 2.5??M). The confidence limit of *p?

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Psychopharmacol. (Oxford)