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Fig. 2

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ZDB-FIG-250506-33

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Maciag et al., 2025 - Exploring the impact of MDMA and oxytocin ligands on anxiety and social responses: A comprehensive behavioural and molecular study in the zebrafish model

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Fig. 2

Diazepam elicits anxiolytic activity in 3-week-old fish. To validate the methodology used in further studies, we decided to test diazepam (10??M) in the novel environment exploration test under light and dark conditions. Diazepam was able to increase distance moved (a) and time spent (b) in the inner zone by fish, and the effects were not ascribed to changes in locomotion (c) under light conditions. Similar effects were observed under dark conditions; diazepam increased distance moved (d) and time spent (e) in the inner zone by fish without affecting their overall movement (f). This confirms the anxiolytic activity of diazepam and the reliability of our method. Data were analysed using the Mann?Whitney test. The confidence limit of *p?

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Psychopharmacol. (Oxford)