FIGURE

Figure 1

ID

ZDB-FIG-250428-24

Publication

Ferrer et al., 2025 - Hexasodium Fytate (SNF472 or CSL525) Inhibits Ectopic Calcification in Various Pseudoxanthoma Elasticum and Calcinosis Cutis Animal Models

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

Effects of CSL525 on in vitro calcification of human vascular smooth muscle cells (hVSMCs). (A) Calcium content in cultures following calcification induction with 3.3 mM phosphate (P) and increasing concentrations of CSL525 for 21 days. (B) Calcium content in cultures following calcification induction with 3 mM P and 3 mM calcium (Ca) in the presence of increasing concentrations of CSL525 for 14 days. (C) Inhibition of calcification by CSL525 when added at the start of calcification induction. (D) Calcium content in cultures after 7 days of calcification induction with 3 mM P and 3 mM Ca, followed by CSL525 treatment initiated on day 7. (E) Inhibition of calcification by CSL525 when added after 7 days of calcification induction. Results are presented as mean ± SD. Statistical analysis: one-way ANOVA with Tukey’s post hoc test. (**) p < 0.01, (***) p < 0.001, (****) p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Pharmaceuticals (Basel)