FIGURE

Fig. 5

ID

ZDB-FIG-250421-83

Publication

Bellitto et al., 2025 - A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease

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Fig. 5

(a) Scatterplot showing the most significant GO terms emerging from proteomic analysis at 10 dpf in the zebrafish Tg(gfap:hGFAP(R239C)-GFP) larvae compared to Tg(gfap:GFP)mi2001 controls. (b) Scatterplot showing the most significant GO terms emerging from proteomic analysis of 20-dpf Tg(gfap:hGFAP(R239C)-GFP) and Tg(gfap:GFP)mi2001 larvae. Analysis was performed with Revigo, which uses Multidimensional Scaling (MDS) to reduce the dimensionality of a matrix of the GO terms pairwise semantic similarities. The resulting projection may be highly nonlinear. Connected similar GO terms remain close together in the plot; the semantic space units have no intrinsic meaning. Bubble color indicates the p-value for the false discovery rates; circle size indicates the frequency of the GO term in the underlying GO database, where bubbles of more general terms are larger.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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