FIGURE

Fig. 2

ID

ZDB-FIG-250401-19

Publication

Li et al., 2025 - Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish

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Fig. 2

Genetic inhibition of adrb1 signaling could rescue CCM in ccm2 CRISPR zebrafish. (A through F) Representative light sheet microscopy scanning pictures of brains from ccm2 CRISPR adult zebrafish of adrb1+/+ (A through C) and of adrb1-/- (D through F) onTg(fli1:EGFP) background. Brains from ccm2 CRISPR on wild type background show lesions indicated by arrows (A through C), while brains from ccm2 CRISPR on adrb1-/- do not show lesions (D through F). Scale bar: 1 mm. (G) Statistical analysis of total lesion volume by unpaired two-tailed t test. p=0.0005. 12 adrb1-/- brains and 13 adrb1+/+ brains were analyzed.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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