Phenotype
|
Fish
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Conditions
|
Figures
|
spinal cord morphology, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
heart dilated, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
control
|
Figure 5 ,
Figure 6
from Li et al., 2021
|
cerebellum brain vasculature morphology, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
brain anatomical surface lesioned, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
brain vasculature dilated, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
brainstem morphology, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
nucleate erythrocyte accumulation brain vasculature, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
brain vasculature morphology, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
caudal vein plexus dilated, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
control
|
Figure 4 ,
Figure 5 ,
Figure 6
from Li et al., 2021
|
forebrain brain vasculature morphology, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
brain hemorrhagic, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
caudal vein plexus structure, ameliorated
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment by environment: Y-27632
|
Figure 7 - figure supplement 2
from Li et al., 2021
|
caudal vein plexus structure, cavities, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
control
|
Figure 7 - figure supplement 2
from Li et al., 2021
|
caudal vein plexus dilated, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-ccm2
|
standard conditions
|
Figure 6
from Li et al., 2021
|
heart dilated, abnormal
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-ccm2
|
standard conditions
|
Figure 6
from Li et al., 2021
|
developmental vascular plexus endothelial cell EGFP expression increased amount, abnormal
|
ig11Tg; is5Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 4
from Li et al., 2021
|
developmental vascular plexus endothelial cell EGFP expression spatial pattern, abnormal
|
ig11Tg; is5Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 4
from Li et al., 2021
|
caudal vein plexus dorsal side dilated, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: (R)-(+)-propranolol
|
Fig. 1
from Li et al., 2020
|
caudal vein plexus dorsal side dilated, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
control
|
Fig. 1,
Fig. 2
from Li et al., 2020
|
caudal vein plexus ventral side absent, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: (R)-(+)-propranolol
|
Fig. 1
from Li et al., 2020
|
blood circulation decreased process quality, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 1
from Li et al., 2021
|
caudal vein dorsal side diameter, ameliorated
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: propranolol
|
Fig. 1
from Li et al., 2020
|
subintestinal vein increased branchiness, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 1 - figure supplement 2
from Li et al., 2021
|
intussusceptive angiogenesis arrested, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 2
from Li et al., 2021
|
caudal vein plexus folded, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: (R)-(+)-propranolol
|
Fig. 1
from Li et al., 2020
|
caudal vein plexus folded, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
control
|
Fig. 1,
Fig. 2
from Li et al., 2020
|
caudal vein plexus ventral side absent, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
control
|
Fig. 1,
Fig. 2
from Li et al., 2020
|
heart dilated, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
control
|
Figure 1 ,
Figure 1 - figure supplement 2
from Li et al., 2021
Fig. 1
from Li et al., 2020
|
nucleate erythrocyte accumulation caudal vein plexus, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 1 ,
Figure 2
from Li et al., 2021
|
caudal vein plexus dilated, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 1 ,
Figure 2
from Li et al., 2021
|
caudal vein plexus ventral side present, ameliorated
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: propranolol
|
Fig. 1
from Li et al., 2020
|
caudal vein dorsal side diameter, ameliorated
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: metoprolol
|
Fig. 2
from Li et al., 2020
|
caudal vein plexus structure, cavities, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 1 ,
Figure 2
from Li et al., 2021
|
caudal vein plexus anatomical surface irregularly shaped, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 2
from Li et al., 2021
|
heart dilated, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: (R)-(+)-propranolol
|
Fig. 1
from Li et al., 2020
|
caudal vein plexus morphology, ameliorated
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: propranolol
|
Fig. 1
from Li et al., 2020
|
cranial blood vessel dilated, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 1
from Li et al., 2021
|
caudal vein plexus lumen obstructed, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 2
from Li et al., 2021
|
heart dilated, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
chemical treatment: propranolol
|
Fig. 1
from Li et al., 2020
|
caudal vein plexus size, ameliorated
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-gata1a
|
standard conditions
|
Figure 4
from Li et al., 2021
|
caudal vein plexus size, ameliorated
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-tnnt2a
|
standard conditions
|
Figure 4
from Li et al., 2021
|
caudal vein plexus size, ameliorated
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO3-trim33
|
standard conditions
|
Figure 4
from Li et al., 2021
|
caudal vein plexus size, ameliorated
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-klf2a + MO2-klf2b
|
control
|
Figure 5
from Li et al., 2021
|
heart size, ameliorated
|
y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-klf2a + MO2-klf2b
|
control
|
Figure 5
from Li et al., 2021
|
caudal vein plexus endothelial cell EGFP expression increased amount, abnormal
|
ig11Tg; is5Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-tnnt2a
|
standard conditions
|
Figure 4
from Li et al., 2021
|
brain vasculature morphology, ameliorated
|
klf2aig4/ig4; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2
|
standard conditions
|
Figure 7
from Li et al., 2021
|
caudal vein plexus dorsal side dilated, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-adrb2a
|
control
|
Fig. 2
from Li et al., 2020
|
caudal vein plexus folded, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-adrb2a
|
control
|
Fig. 2
from Li et al., 2020
|
caudal vein plexus ventral side absent, abnormal
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-adrb2a
|
control
|
Fig. 2
from Li et al., 2020
|
caudal vein plexus ventral side present, ameliorated
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO2-adrb1
|
control
|
Fig. 2
from Li et al., 2020
|
caudal vein plexus morphology, ameliorated
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO2-adrb1
|
control
|
Fig. 2
from Li et al., 2020
|
caudal vein dorsal side diameter, ameliorated
|
sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO2-adrb1
|
control
|
Fig. 2
from Li et al., 2020
|