FIGURE

Fig. 4

ID

ZDB-FIG-250311-79

Publication

Patra et al., 2025 - Nephronectin Is Required for Vascularization in Zebrafish and Sufficient to Promote Mammalian Vessel-Like Structures in Hydrogels for Tissue Engineering

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Fig. 4

npnta mutants phenocopy the axial vessel phenotypes of npnta morphants. A, Maximum intensity projections of confocal images of the caudal vein plexus forming region. Yellow arrowheads indicate ventral angiogenic sprouts at the axial vein. B, Quantification of angiogenic sprouts from AV at 28 hpf (n=11 embryos for each group). Angiogenic sprouts in the control embryos were considered as 100%. C, Maximum intensity projections of confocal images of the posterior somite region. Yellow arrows: intersegmental vessels that reached the dorsal lateral anastomotic vessel. Magenta arrows: ISVs that are yet to reach the DLAV. D, Quantification of the ISVs out of 8 post?cloaca ISVs that reached the DLAV at 30 hpf (n=10 embryos for each group). Statistical significance in B and D was determined by a 2?tailed Student's t test. Data are mean�SEM. ****P?0.0001. AV indicates axial vein; DLAV, dorsal lateral anastomotic vessel; hpf, hours post fertilization; and ISV, intersegmental vessel.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Am. Heart Assoc.