FIGURE

Fig. 5

ID

ZDB-FIG-250217-32

Publication

Mazzaferro et al., 2025 - Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

The effect of CRISPR/Cas9-induced mutations in 13 obesity genes on food intake in 8-day-old CRISPR/Cas9 founders. Dots and error bars show effect sizes and 95% confidence intervals for affected larvae (number on the left) vs. controls (number on the right). The effect of being in the first quartile of food intake [Q1]; left); the effect of being in the third quartile (Q3; middle); the effect of being in the top quartile (Q4; right). All are compared with the second quartile (Q2) as a reference. The results for irs2 and lep are derived from the concurrent targeting of both orthologues (i.e., irs2a and irs2b; lepa and lepb). Effects have been adjusted for batch, tank and time of day at imaging. Effects with P < 0.05 are shown in red.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.