FIGURE

Figure 5

ID

ZDB-FIG-250110-104

Publication

Rostad et al., 2024 - Accelerated Sarcopenia Phenotype in the DJ-1/Park7-Knockout Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 5

Absence of DJ-1 facilitates an age-dependent decrease in muscle NAD⁺/NADH ratio. Metabolites were measured using targeted mass spectrometry on whole muscle from different age groups. A two-way ANOVA analysis was conducted on the (A) NAD⁺/NADH and (B) NADP⁺/NADPH ratios of 10 log-transformed data. A significant age-dependent reduction in the NAD⁺/NADH ratio was found in both DJ-1 KO and WT (F (2, 23) = 37.78, p < 0.0001). No significant age-dependent effect was found in the NADP⁺/NADPH ratio (F (1, 21) = 0.007642, p = 0.2532). The represented p-values comparing age groups from the same genotype were obtained from a Tukey multiple comparisons test on the Log10-transformed data.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	park7^{ub2000/ub2000} (AB/TU)
Observed In:	muscle NAD+ biosynthetic process
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)