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Figure 5

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Publication: Rostad et al., 2024 - Accelerated Sarcopenia Phenotype in the DJ-1/Park7-Knockout Zebrafish
All Figures: Figures for Rostad et al., 2024

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Figure 5

Absence of DJ-1 facilitates an age-dependent decrease in muscle NAD⁺/NADH ratio. Metabolites were measured using targeted mass spectrometry on whole muscle from different age groups. A two-way ANOVA analysis was conducted on the (A) NAD⁺/NADH and (B) NADP⁺/NADPH ratios of 10 log-transformed data. A significant age-dependent reduction in the NAD⁺/NADH ratio was found in both DJ-1 KO and WT (F (2, 23) = 37.78, p < 0.0001). No significant age-dependent effect was found in the NADP⁺/NADPH ratio (F (1, 21) = 0.007642, p = 0.2532). The represented p-values comparing age groups from the same genotype were obtained from a Tukey multiple comparisons test on the Log10-transformed data.

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Phenotype details

Acknowledgments

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