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Figure 10

ID

ZDB-FIG-250109-319

Publication

Ten Martin et al., 2024 - Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes

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Figure 10

Schematic representation of MT-severing enzyme selective regulation by specific TTLL enzymes in zebrafish and mammalian neurons.

(A) Upper panel: TTLL6-mediated tubulin polyglutamylation selectively tunes p60-Katanin activity in zebrafish dorsally projecting secondary motor axons to control their targeting. Lower panel: TTLL11-driven MT polyglutamylation is required for accurate axon pathfinding of rostrally projecting secondary motor nerves in zebrafish larvae. (B) Spastin haploinsufficiency induces axonal swellings in mammalian cortical neurons (middle panel), which can be selectively rescued by promoting TTLL11-mediated tubulin polyglutamylation (lower panel), most likely through the boosting of residual spastin activity upon the critical threshold (i.e., 50%).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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