ZFIN Image: Ten Martin et al., 2024, Figure 10

Image

Figure Caption

Figure 10 Schematic representation of MT-severing enzyme selective regulation by specific TTLL enzymes in zebrafish and mammalian neurons.

(A) Upper panel: TTLL6-mediated tubulin polyglutamylation selectively tunes p60-Katanin activity in zebrafish dorsally projecting secondary motor axons to control their targeting. Lower panel: TTLL11-driven MT polyglutamylation is required for accurate axon pathfinding of rostrally projecting secondary motor nerves in zebrafish larvae. (B) Spastin haploinsufficiency induces axonal swellings in mammalian cortical neurons (middle panel), which can be selectively rescued by promoting TTLL11-mediated tubulin polyglutamylation (lower panel), most likely through the boosting of residual spastin activity upon the critical threshold (i.e., 50%).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO J.