FIGURE

Figure 5

ID

ZDB-FIG-250109-283

Publication

Wang et al., 2024 - Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations

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Figure 5

IGF2BP2 and LGALS8 regulate vascular development in the zebrafish model. (A,B) Schematic of CRISPR/Cas9-mediated generation of igf2bp2a/b crispant zebrafish and identification via RNA-sequencing. (C) Representative images of cerebrovascular structures and (D) statistical analysis of mid- and hind-brain vascular areas in control and igf2bp2a/b crispant zebrafish. (E) Representative images of cerebrovascular structures and (F) statistical analysis of mid- and hind-brain vascular areas in igf2bp2a/b crispant and rescue zebrafish. (G,H) Schematic of CRISPR/Cas9-mediated generation of lgals8a/b crispant zebrafish and identification via RNA-sequencing. (I) Representative images of cerebrovascular structures and (J) statistical analysis of mid- and hind-brain vascular areas in control and lgals8a/b crispant zebrafish. (K) Representative images of cerebrovascular structures and (L) statistical analysis of mid- and hind-brain vascular areas in lgals8a/b crispant and rescue zebrafish. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Neurol