FIGURE

Fig 7

ID

ZDB-FIG-250109-260

Publication

Fietta et al., 2024 - Neuroblastoma-derived hypoxic extracellular vesicles promote metastatic dissemination in a zebrafish model

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Fig 7

Hypoxic EVs promote the proliferation of NB cells in the CHT.

A. Injection site, analysis site, and timeline for Tg(fli1:EGFP) embryos injected with NB-derived EVs and NB cells. Embryos were injected with EVs isolated from SK-N-DZ or IMR32 cells cultured in normoxic or hypoxic conditions, and subsequently injected with SK-N-DZ and IMR32 cells, respectively. B. Representative CHT images 24 hpi of EVs and 18 hpi of SK-N-DZ cells (orange). Scale bar 100 μm. C. Representative CHT images 24 hpi of EVs and 18 hpi of IMR32 cells (orange). Scale bar 100 μm. D. Evaluation of proliferated SK-N-DZ cells area in the CHT at 72 hpf. n = 53 from at least 3 independent experiments. * p < 0.05. E. Evaluation of proliferated IMR32 cells area in the CHT at 72 hpf. n = 59 from at least 3 independent experiments. * p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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