FIGURE

Fig. 6

ID

ZDB-FIG-250103-10

Publication

Niu et al., 2024 - An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis

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Fig. 6

IL10 controls blood vessel organoid (BVO) development and enhances vasculogenesis and angiogenesis. 3000 undifferentiated hiPSCs were induced to form BVOs over 15 days in the presence of 1 µg/ml anti-IL10 antibody, 20 ng/ml IL10, or respective control (IgG or Ctrl) during mesoderm induction stage. Day 9 of BVOs were collected and subjected to HE (A-B) and IF staining (C-D) analysis, respectively. Image J was used for measuring BVO size (B) and CD31-positive area within BVOs (D), respectively. # in (A) indicates angiogenic zone. The data presented here are representative (A and C) and mean±S.E.M (B and D) of three independent experiments (n=3). *P<0.05 (vs IgG or Ctrl).

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Eur. J. Cell Biol.