FIGURE

Fig. 5

ID

ZDB-FIG-241120-42

Publication

Baril et al., 2024 - The role of ATP-binding Cassette subfamily B member 6 in the inner ear

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Fig. 5

Zebrafish Abcb6 MO15 morpholino affects otolith development in zebrafish.

a Zebrafish Abcb6 MO15 disrupts formation of the utricular otolith (black arrow), while uninjected controls retain both utricular (black arrow) and saccular (white arrow) otoliths at 1-, 5-, and 14-days post-fertilization (dpf). b Uninjected wild-type fish with AB (i) and p53-null (iii) backgrounds develop normal otoliths, while Abcb6 morphants (ii and iv) fail to develop the utricular otolith. c The single otolith phenotype can be rescued by co-injection with human ABCB6 mRNA. Data for uninjected control (N = 25 fish), zebrafish abcb6 mRNA (N = 9 fish), Abcb6 MO15 (N = 20 fish), and Abcb6 MO15 + human ABCB6 mRNA (N = 19 fish) can be found in Supplementary Table 4 or the source data file. Injections were repeated and the results showed the same pattern.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1 (AB) AB + MO8-abcb6a tp53^zdf1/zdf1 + MO8-abcb6a (AB)
Knockdown Reagent:	MO8-abcb6a
Observed In:	lapillus sagitta
Stage Range:	Prim-5 to Days 14-20

Phenotype Detail

Acknowledgments

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