FIGURE

Fig. 5

ID
ZDB-FIG-241120-42
Publication
Baril et al., 2024 - The role of ATP-binding Cassette subfamily B member 6 in the inner ear
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Fig. 5

Zebrafish Abcb6 MO15 morpholino affects otolith development in zebrafish.

a Zebrafish Abcb6 MO15 disrupts formation of the utricular otolith (black arrow), while uninjected controls retain both utricular (black arrow) and saccular (white arrow) otoliths at 1-, 5-, and 14-days post-fertilization (dpf). b Uninjected wild-type fish with AB (i) and p53-null (iii) backgrounds develop normal otoliths, while Abcb6 morphants (ii and iv) fail to develop the utricular otolith. c The single otolith phenotype can be rescued by co-injection with human ABCB6 mRNA. Data for uninjected control (N = 25 fish), zebrafish abcb6 mRNA (N = 9 fish), Abcb6 MO15 (N = 20 fish), and Abcb6 MO15 + human ABCB6 mRNA (N = 19 fish) can be found in Supplementary Table 4 or the source data file. Injections were repeated and the results showed the same pattern.
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Prim-5 to Days 14-20

Phenotype Detail
Acknowledgments
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