FIGURE

Fig. 1

ID

ZDB-FIG-241115-128

Publication

Shin et al., 2024 - Harnessing the regenerative potential of interleukin11 to enhance heart repair

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Fig. 1

Spatiotemporal il11a expression during heart regeneration in adult zebrafish.

a Representative cardiac section images of il11a^EGFP. Uninj, Uninjured. dpa, days post-amputation. b Quantification of EGFP expression area near the wound area. Biological replicates = 4, 3, 3, and 3 for uninjured and 3, 7, and 14 dpa hearts, respectively. Comparison of il11a^EGFP expressing cells with kdrl:mCherry (c) and tcf21:mCherry (d) in 3 dpa hearts. kdrl:mCherry and tcf21:mCherry represent endocardium and epicardium, respectively. Dash boxes correspond to the region magnified in the panels below. Dotted lines demarcate the amputation plane. Scale bars, 100 µm in (a), 50 µm in (c) and (d). Data are mean ± SEM in (b). p-values were determined by one-way ANOVA with Dunnett’s multiple comparison test in (b).

Expression Data

Gene:	EGFP
Fish:	il11a^{uwk25Tg/uwk25Tg}; ci5Tg/ci5Tg il11a^{uwk25Tg/uwk25Tg}; pd108Tg/pd108Tg
Condition:	resection: cardiac ventricle
Anatomical Terms:	cardiac ventricle regenerating tissue endocardium epicardium
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	il11a^{uwk25Tg/uwk25Tg}; ci5Tg/ci5Tg il11a^{uwk25Tg/uwk25Tg}; pd108Tg/pd108Tg
Condition:	resection: cardiac ventricle
Observed In:	cardiac ventricle regenerating tissue
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.