FIGURE

Fig 6

ID

ZDB-FIG-241101-25

Publication

Meserve et al., 2024 - Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit

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Fig 6

FBMN migration is independent of celsr3.

A-D) isl1:GFP transgene expression of cytosolic GFP in 48 hours post-fertilization (hpf) facial branchiomotor neurons (FBMNs) in sibling (A), celsr2^-/- (B), celsr3^-/- (C), and celsr3^-/-;celsr2^-/- (D) embryos. α-3A10 labels Mauthner somas and axons (left panels). Approximate rhombomere boundaries (r4, r5, r6) are indicated with brackets (right panels). Asterisks in (C,D) denote presumptive dying Mauthners based on soma morphology. Scale bars = 20 μM, Z-projection. E) Percent of larvae with full (e.g. A,C), intermediate (e.g. D), and minimal (e.g. B) FBMN migration. n = 75 sib, 32 celsr3^-/-, 11 celsr2^-/-, 10 celsr3^-/-;celsr2^-/-. p-value calculated with Fisher’s exact test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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