FIGURE

Figure 5.

ID
ZDB-FIG-241017-128
Publication
Thomas et al., 2024 - Second generation lethality in RNAseH2a knockout zebrafish
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Figure 5.

Embryos from older rnaseh2a−/− fish are significantly underdeveloped compared with embryos from younger fish. (A) Movement analysis of adult zebrafish revealed the distance moved by rnaseh2a−/− is significantly shorter than rnaseh2a+/+ adults. Unpaired t-test, n = 10, individual adults, ±SD, ** P < 0.001. (B) Photomoter response of embryos from rnaseh2a+/− parents show no significant difference in distance moved by rnaseh2a+/+ compared with rnaseh2a−/− ±SD, unpaired t-test, n = P < 0.05. (C) Representative images of embryos from 6 month old and 12 month old rnaseh2a−/− zebrafish. (D) Quantification of embryo length from old and young zebrafish n = 36, individual embryos. Unpaired t-test **** P < 0.0001. (E) RTqPCR showing an increase in the expression level of ISG15 in embryos resulting from older rnase2a−/− adults. n = 3, 20 pooled embryos. Unpaired t-test P < 0.05.
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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