FIGURE

Fig. 4

ID

ZDB-FIG-241016-44

Publication

Zareba et al., 2024 - NPC1 links cholesterol trafficking to microglial morphology via the gastrosome

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Fig. 4

NPC1 localizes on the gastrosome that accumulates apoptotic material.a Representative image of RAW NPC1-EGFP macrophages stained for LAMP1 (N = 2, more than 4 cells examined per condition in each repetition). Scale bar 10 �m. b Representative images of RAW NPC1-EGFP macrophages from in vitro feeding experiment. Gastrosome indicated by orange arrowhead. For HeLa-fed U18666a treated example, single plane view shown in a box for NPC1-EGFP (N = 2, more than 4 cells examined per condition in each repetition). Scale bar 10 �m. c, Representative images of OT (TgBAC(csf1ra:GAL4-VP16), Tg(UAS-E1B:NTR-mCherry; npc1:mNeonGreen)) zebrafish microglia showing localization of NPC1 displayed as maximum projection and segmentation (N = 4). Scale bar 10 �m. N refers to the number of experimental replicates. OT stands for optic tectum.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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