FIGURE

Fig. 7

ID

ZDB-FIG-240903-43

Publication

Dondi et al., 2024 - The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy

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Fig. 7

CRTC affects cardiac function in hiPSC-cardiomyocytes (A) Representative voltage traces from control siRNA- and siCRTC-transfected cardiomyocytes. APs were recorded optically from individual cardiomyocytes. APD at 75% of repolarization (APD75) was significantly increased with siRNA-mediated KD of CRTC2 and CRTC3. (Plots show max, min, median, and p values; siCtrl n = 1,338, siCRTC1 n = 1,459, siCRTC2 n = 1,427, siCRTC3 n = 1,326; significance by one-way ANOVA with Tukey?s multiple comparisons post hoc test). (B) RT-qPCR quantification showing reduction in SRL expression in iPSC-CMs after siRNA CRTC KD. (Significance by one-way ANOVA with Tukey?s multiple comparisons post hoc test). (C) siRNA KD of SRL prolongs APD75 in hiPSC-CMs (unpaired t test). (D) Model of proposed CaN-CRTC-SRL signaling pathway.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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