Fig. 2

Cell-cell interaction networks during spinal cord regeneration. A Relative strengths of outgoing signaling pathways in major spinal cell populations at 0, 1, 3 and 6 wpi. Bar graphs at the top of each heatmap show cumulative signaling strengths per cell population. Bar graphs at the right of each heatmap show cumulative signaling strength per pathway. Pathways highlighted in yellow are specifically enriched at one time point. Pathways highlighted in magenta are enriched after injury. B Cumulative strengths of signaling pathways outgoing from or received by major cell types. C Circle plots represent cell-cell interaction strengths of signaling pathways outgoing from Neurons A, B and OPCs at 6 wpi. Arrow thickness is proportional to the cumulative strengths of all predicted interactions between clusters. D Chord diagrams showing intercellular communication of signaling pathways that are enriched in neurons after spinal cord injury (SCI). Arc diameters are proportional to cumulative signaling strengths. Bar graphs at the bottom of each chord diagram represent the relative contribution of different ligand-receptor pairs predicted for each signaling pathway. Source data are provided as a Source Data file.