FIGURE

Fig. 2

ID

ZDB-FIG-240712-15

Publication

Cui et al., 2024 - Lens autophagy protein ATG16L1: a potential target for cataract treatment

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Fig. 2

ATG16L1 effectively relieves lens differentiation defects in cx50-deficient zebrafish. (A) Representative images show the distribution of nuclei and F-actin in the lenses of 72 hpf WT, cx50-deficient zebrafish, and cx50-deficient zebrafish injected with the vector or ATG16L1 plasmid. Scale bar: 10 �m. (B) Quantification of the severity of lens defects and the number of nuclei in lenses of each group (n > 25 zebrafish for each group). Mann-Whitney test. (C) Electron micrographs of lenses in 72 hpf WT, cx50-deficient zebrafish, and cx50-deficient zebrafish injected with the ATG16L1 plasmid. Yellow arrows indicate autophagic vacuoles (AVs), scale bar: 1 �m. (D) The number of AVs per area (40 ?m2) in each group (n ? 30 cells from 5 lenses). Mean � SD, *p < 0.05. N.S. not significant (Mann-Whitney test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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