FIGURE

Fig. 5

ID

ZDB-FIG-240620-110

Publication

Dong et al., 2024 - Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractility

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Fig. 5

Necdin regulated MYL12A stability in a SGT1- and HSP90-dependent manner (A and B) Necdin failed to increase MYL12A protein levels in Sgt1-depleted (siSgt1) H9C2 cells. Representative immunoblots (A) and statistics data of three independent experiments (B) are shown. Data are presented as means ± SEM, ?p < 0.05, unpaired t test. (C and D) Necdin failed to increase MYL12A protein levels in H9C2 cells treated with HSP90 inhibitor GA. Representative immunoblots (C) and statistics data of three independent experiments (D) are shown. Data are presented as means ± SEM, ?p < 0.05, unpaired t test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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