Figure 2
- ID
- ZDB-FIG-240604-16
- Publication
- Chen et al., 2024 - Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation
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Conditional deletion of mouse Styxl2 leads to defective sarcomeres in striated muscles. (A) The expression of Styxl2 protein in skeletal muscles of wild-type (+/+), heterozygous (+/?), and Styxl2 knockout (KO) (?/?) (driven by EIIA-Cre) mice. Soluble tissue lysates from limbs of E14.5 mouse embryos were subjected to Western blot analysis. N.S.: non-specific. (B) E14.5 embryos of control (Ctrl) and EIIA-Cre; Styxl2f/f KO mice. *: edema was found in some Styxl2 KO foetuses. (C) The sarcomere structures of cardiomyocytes in the heart of E14.5 embryos from control and EIIA-Cre; Styxl2f/f KO mice were revealed by transmission electron microscopy (TEM). Scale bar: 1 ?m. (D) The expression of Styxl2 protein in skeletal muscles of control (Ctrl) and Styxl2 CKO P1 mice. (E) The new-born pups (P1) from control (Ctrl) and Pax7Cre/+; Styxl2f/f KO mice (CKO). (F) Lung sections of control and Styxl2 CKO P1 mice. Scale bar: 50 ?m. (G) The sarcomere structure of diaphragm muscles from control (Ctrl) and Styxl2 conditional KO (CKO) P1 mice revealed by TEM. Scale bar: 1 ?m |