FIGURE

Fig 3

ID

ZDB-FIG-240531-146

Publication

Inoue et al., 2024 - Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy

Other Figures

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Fig 3

Larsb-knockin larvae display liver abnormality during the liver developmental stage. A Diagram showing the larsb genomic locus and larsb-knockin (larsb-I451F) zebrafish mutant genotype. B In the genomic sequencing analysis chromatograms, the mutation site in the larsb-I451F zebrafish is shown in red. C Morphological abnormality at 4 to 7 dpf in the livers of larsb-I451F larvae with a Tg[fabp10:mcherry] background. White arrows indicate the loss of liver edges in larsb-I451F larvae. Scale bar: 200 μm. D Relative liver area in larsb-WT (n = 15 fish) and larsb-I451F (n = 9 fish) larvae with a Tg[fabp10:mcherry] background (4 to 7 dpf). *P < 0.05. E Circularity of liver in larsb-WT (n = 15 fish) and larsb-I451F (n = 9 fish) larvae with a Tg[fabp10:mcherry] background (4 to 7 dpf). Error bars indicate SEM. *P < 0.05, **P < 0.01

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lars1b^oi12/oi12; oi2Tg (AB)
Observed In:	liver
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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