FIGURE

Fig. 5

ID

ZDB-FIG-240523-18

Publication

Zhao et al., 2024 - Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish

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Fig. 5

Effect of P2RY11 mutation on the expression of genes related to the immune system process. A, Quantitative analysis of the expression of il6, tnfa, il1b, il4, il10 and tgfb. (n = 20). B, Gene Ontology analysis of the DE genes related to the immune system process. C, The relationship of the enriched GO terms. D, Heatmap demonstrating downregulation of genes in P2RY11^−/− mutants involved in the main enriched terms (n = 3). E, qRT-PCR validation of the RNA-seq data. Downregulation of cxcl20, cora1a, ccl39.3, ccl34b.1, cyba, mpeg1, mmp13a, lyz (n = 20). T-test was performed, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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