FIGURE

Fig 8

ID

ZDB-FIG-240416-41

Publication

Jiang et al., 2024 - The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b

Other Figures

All Figure Page

Back to All Figure Page

Fig 8

Model

RA signaling induces the transcription of rcan2, an endogenous inhibitor of calcineurin, to alleviate calcineurin inhibition of Kcnk5b channel activity. Kcnk5b decreases intracellular K⁺ levels in the mesenchyme that increase depolarization to promote IP₃R-mediated Ca²⁺ release from the ER. The increase in intracellular Ca²⁺ activates CaMKK, and both are required for the increased transcription of shha and enhanced growth of the pectoral fin buds by Kcnk5b. ER, endoplasmic reticulum; RA, retinoic acid.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.