FIGURE

Fig. 1

ID

ZDB-FIG-240408-25

Publication

Zhang et al., 2024 - Astaxanthin activates the Nrf2/Keap1/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity

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Fig. 1

Developmental toxicity and neurological abnormalities were observed in embryonic zebrafish exposed to TPhP. (A-D) Effects of TPhP exposure on AchE, DA, ATPase and GST levels in zebrafish larvae at 96 hpf. (E) Expression analysis of genes along the nervous system. (F) Expression analysis of genes related to neurodevelopment. The treatment groups were composed of three replicates, each containing 25 larvae. (G) Tg (elav13/huc: EGFP) transgenic zebrafish with green fluorescence were used to mark axons of Purkinje neurons. (H-J) Each group exposed to TPhP showed the green fluorescence of transgenic Tg (sox10: EGFP) zebrafish (72 hpf, 96 hpf and 7 dpf) that marked neural crest origin cells. Values represent mean ± SEM. In comparison with the control group, * p < 0.05, * * p < 0.01 (one-way ANOVA and LSD test was employed).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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