FIGURE

Fig 8

ID

ZDB-FIG-240331-45

Publication

Guerrero-Lim�n et al., 2024 - A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling

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Fig 8

Schematic diagram of the effects of POP125× on skeletal development.

Represented is the bone-forming osteoblast cell, originating from pre-osteoblastic, mesenchymal cells through expression of regulatory genes such as runx2b or sp7. They secrete the collagenous (Coln) bone ECM, which itself is subsequently mineralized through deposition of CaPO₄ cristals. POP125× inhibits mineralized bone formation primarily by interfering with collagen secretion, acting on the vitamin D (vit D3), the retinoic acid (RA), and/or the androgen receptor (AR) pathways.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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