FIGURE

Fig 8

ID
ZDB-FIG-240331-45
Publication
Guerrero-Limón et al., 2024 - A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling
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Fig 8

Schematic diagram of the effects of POP125× on skeletal development.

Represented is the bone-forming osteoblast cell, originating from pre-osteoblastic, mesenchymal cells through expression of regulatory genes such as runx2b or sp7. They secrete the collagenous (Coln) bone ECM, which itself is subsequently mineralized through deposition of CaPO4 cristals. POP125× inhibits mineralized bone formation primarily by interfering with collagen secretion, acting on the vitamin D (vit D3), the retinoic acid (RA), and/or the androgen receptor (AR) pathways.
Expression Data

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Antibody Labeling
Phenotype Data

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Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One
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