FIGURE

Fig 8

ID

ZDB-FIG-240331-45

Publication

Guerrero-Limón et al., 2024 - A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling

Other Figures

All Figure Page

Back to All Figure Page

Fig 8

Schematic diagram of the effects of POP125× on skeletal development.

Represented is the bone-forming osteoblast cell, originating from pre-osteoblastic, mesenchymal cells through expression of regulatory genes such as runx2b or sp7. They secrete the collagenous (Coln) bone ECM, which itself is subsequently mineralized through deposition of CaPO₄ cristals. POP125× inhibits mineralized bone formation primarily by interfering with collagen secretion, acting on the vitamin D (vit D3), the retinoic acid (RA), and/or the androgen receptor (AR) pathways.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One