IMAGE

Fig 8

ID
ZDB-IMAGE-240331-46
Publication
Guerrero-Limón et al., 2024 - A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling
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Figures for Guerrero-Limón et al., 2024
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Figure Caption

Fig 8 Schematic diagram of the effects of POP125× on skeletal development.

Represented is the bone-forming osteoblast cell, originating from pre-osteoblastic, mesenchymal cells through expression of regulatory genes such as runx2b or sp7. They secrete the collagenous (Coln) bone ECM, which itself is subsequently mineralized through deposition of CaPO4 cristals. POP125× inhibits mineralized bone formation primarily by interfering with collagen secretion, acting on the vitamin D (vit D3), the retinoic acid (RA), and/or the androgen receptor (AR) pathways.

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