FIGURE

Fig. 5

ID

ZDB-FIG-240323-5

Publication

Ma et al., 2024 - METTL3-dependent m⁶A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

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Fig. 5

psen1 rescues the level of Sox10 associated with migrating zebrafish neural crest cells and abnormal craniofacial phenotypes.

A, B Co-injection of psen1 mRNA rescued the abnormal craniofacial phenotypes in mettl3-knockdown embryos. C Statistical analysis of the number of dead, abnormal, or normal embryos. D Scatter histogram showing the length of the palatoquadrate, Meckel’s cartilage, and the ethmoid plate; the width of Meckel’s cartilage and the ethmoid plate; and the distance of the mouth opening in zebrafish embryos injected with control MO, mettl3 MO, or co-injection with mettl3 MO and psen1 mRNA (each group, n = 100). E Iridophores at 48, 72, and 96 hpf in zebrafish embryos injected with control MO, mettl3 MO, or co-injection with mettl3 MO and psen1 mRNA. F Tg(sox10: eGFP) transgenic zebrafish embryos expressing green fluorescent protein (GFP) were used to explore the effects of mettl3 and psen1 during zebrafish embryogenesis. Results were presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01 or ***P < 0.001 indicates a significant difference between the groups.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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