FIGURE

Fig. 2

ID

ZDB-FIG-240323-2

Publication

Ma et al., 2024 - METTL3-dependent m⁶A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

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Fig. 2

METTL3 knockdown significantly suppresses cell proliferation and migration in vitro.

A, B The efficiency of METTL3 knockdown in BMSCs, HEPM cells, and DPSCs. The expression of METTL3 was verified at both the mRNA and protein levels. C Representative dot blot showing the m⁶A levels in cells with METTL3 knockdown and control groups. MB, methylene blue staining. D, E Low METTL3 expression significantly reduced the proliferation rate of BMSCs, HEPM cells, and DPSCs. F Low METTL3 expression significantly reduced the migration ability of BMSCs, HEPM cells, and DPSCs. Results were presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01 or ***P < 0.001 indicates a significant difference between the designated groups.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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