FIGURE
Fig. 5
- ID
- ZDB-FIG-240305-9
- Publication
- Zorman et al., 2023 - The overview of development of novel bacterial topoisomerase inhibitors effective against multidrug-resistant bacteria in an academic environment: from early hits to in vivo active antibacterials
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. 5
S. aureus DNA gyrase inhibitory activity and cLogP values of a series of aminopiperidine-naphthyridine NBTIs with substituted phenyl RHS moieties (Kolarič et al., 2021; Kolarič et al., 2021; Kokot et al., 2021). Antibacterial activity is enhanced as we move down the halogen group, from fluorine to bromine, as expected for increase in the halogen-bonding enthalpy. Differential fluorination of the RHS moiety enhances on-target inhibitory potency even further. Despite very similar cLogP values, m-difluorinated show higher antibacterial activity compared to m,o-difluorinated ones. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Eur. J. Pharm. Sci.