FIGURE

FIGURE 1

ID

ZDB-FIG-240213-9

Publication

Ramesh et al., 2024 - Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock

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FIGURE 1

Overview of the Delta-Notch signaling pathway depicting trans-activation and cis-inhibition. Trans-activation is initiated when the DSL domain of the Delta/Serrate/Jagged ligands binds to the extracellular domain of Notch receptors. This initiates two crucial cleavages-the S2 cleavage by the ADAM protease; and subsequently an S3 cleavage by gamma-secretase. The two cleavages result in the production of free NICD that translocates into the nucleus to initiate transcription of target genes. Notch receptors, with are also a target of Notch signaling are subject to a wide range of post-translational modifications in the trans ER-Golgi space by Protein O-Fucosyltransferase (POFUT), Protein O-glucosyltransferase (POGLUT), Lunitic fringe (Lfng), etc., which subsequently affect the type of ligand-receptor interactions and downstream signaling. Illustrations adapted and modified from (Zhou et al., 2022).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol