FIGURE

Figure 1

ID

ZDB-FIG-240212-75

Publication

Ruan et al., 2024 - Estrogen Signaling Inhibits the Expression of anti-Müllerian hormone (amh) and gonadal-soma-derived factor (gsdf) during the Critical Time of Sexual Fate Determination in Zebrafish

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Figure 1

Estrogen enlarged the bi-potential gonad in zebrafish. (A) A schematic showing the procedure of the classification according to PGC area and gene expression analyses. (B) The bi-potential gonad area of the selected cyp17a1+/+ and cyp17a1−/− fish at 23 dpf. Dark green circles: top three bipotential gonad area. Brown circles: last three bi-potential gonad area. (C,D) Representative images of the selected cyp17a1+/+ and cyp17a1−/− fish from the PGC-rich group at 23 dpf. EGFP-labeled gonads were pointed by white arrows. Scale bar, 250 µm. (E,F) Representative images of the selected cyp17a1+/+ and cyp17a1−/− fish from the PGC-less group at 23 dpf. EGFP-labeled gonads were pointed by white arrows. Scale bar, 250 µm. (G) Gene expression heat map of cyp19a1a in cyp17a1+/+ zebrafish from PGC-rich and PGC-less groups at 23 dpf. (H) The bi-potential gonad area of the selected cyp17a1+/+ and cyp17a1−/− fish with estradiol treatment from 16 to 23 dpf. E2, 17 β-estradiol. n.s., no significance. * p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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