FIGURE

Fig. 6

ID

ZDB-FIG-240131-30

Publication

Cao et al., 2023 - A Terphenyllin Derivative CHNQD-00824 from the Marine Compound Library Induced DNA Damage as a Potential Anticancer Agent

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Fig. 6

CHNQD-00824-induced apoptosis and cell cycle arrest in BT549 cells. (A,C) Flow cytometry analysis of cell cycle analysis on BT549 cells after treatment with CHNQD-00824 for 24 h. (B,D) Flow cytometry analysis of BT549 cells stained with the Annexin V/FITC-PI double staining solution after treatment with CHNQD-00824 for 24 h. (E) Effect of CHNQD-00824 on apoptosis-related proteins. BT549 cells were treated with CHNQD-00824 (0–8 μM) for 24 h, then cells were harvested and proteins were separated by electrophoresis on SDS-PAGE. Western blotting analysis were performed to detect the expression of cleaved-PARP, cleaved-caspase-3, Cyto-c and BAD. (F) Histogram shows the relative abundance of apoptosis-related proteins compared with the control group. The data shown are the mean ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns, nonsignificant). n = 3 biological replicate samples.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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