FIGURE

Figure S6.

ID

ZDB-FIG-240111-33

Publication

Heins-Marroquin et al., 2024 - CLN3 deficiency leads to neurological and metabolic perturbations during early development

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Figure S6.

Multivariate and metabolite enrichment analyses of the untargeted metabolomics experiment 2.

(A) Diagram of feature filtering by statistical analysis and compound identification steps. Of 6,373 detected features, 1,125 differed significantly between the WT and MUT1 lines and could be annotated. (B) PCA using all m/z features from the polar extracts detected in positive and negative modes. The first PCA component (PC1) already shows segregation of the metabolites from WT and MUT1 samples. Each dot represents a single biological replicate of WT larvae (black) and MUT1 larvae (blue). (C) Metabolite enrichment analysis of differential metabolites (P < 0.05) highlights the major dysregulated pathways between WT and MUT1 samples in experiment 2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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