FIGURE

FIGURE 1

ID

ZDB-FIG-231228-130

Publication

Valencia-Sama et al., 2023 - SHP2 inhibition with TNO155 increases efficacy and overcomes resistance of ALK inhibitors in neuroblastoma

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FIGURE 1

ALK-mutant neuroblastoma cell lines are sensitive to SHP2 inhibition. A, Protein expression in a panel of neuroblastoma cell lines with ALK-mutant (ALK^mut) or wild-type (ALK^wt) status. Calculation of IC₅₀ in neuroblastoma cells following treatment with TNO155 (B), ceritinib (C), or lorlatinib (D) for 72 hours. **, P < 0.01; ***, P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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