FIGURE

Fig. 8

ID

ZDB-FIG-231213-49

Publication

Chen et al., 2023 - Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish

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Fig. 8

Putative mechanistic map of the mechanisms by which aerobic exercise resists sarcopenia through the miR-128/IGF-1 signaling pathway. d-galactose (d-gal) contributes to the development of sarcopenia by causing metabolic disturbances in vivo to produce large amounts of reactive oxygen species (ROS) and promote the expression of muscle atrophy-related factors MuRF1, Atrogin1, and miR-128. Aerobic exercise inhibits miR-128 expression, which activates the expression of its direct target, insulin-like growth factor-1 (IGF-1). IGF-1 may further promote phosphorylation of FOXO3a by activating PI3K/AKT and PGC1-? signaling pathways. These changes may improve mitochondrial function impaired by d-gal induction, thereby resisting sarcopenia. ATP, adenosine triphosphate; ADP, adenosine diphosphate; SOD, superoxide dismutase.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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