FIGURE

Figure 5

ID

ZDB-FIG-231204-40

Publication

Serrano et al., 2023 - Genetic model of UBA5 deficiency highlights the involvement of both peripheral and central nervous systems and identifies widespread mitochondrial abnormalities

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Figure 5

Quantification of total brain and cerebellar volume in uba5^ex1s/ex1s animals at 6 dpf. (A) Maximum intensity projections of whole brain from Tg (Huc:EGFP); uba5^+/+ and Tg (Huc:EGFP); uba5^ex1s/ex1s 6 dpf zebrafish. (B) Total brain and (C) cerebellar volume analyses showed no significant changes in uba5^ex1s/ex1s (brain volume n = 9, 4, 4, 8, 9; cerebellar volume n = 10, 4, 4, 8, 9) compared to uba5^+/+ (brain volume n = 9, 3, 3, 7, 10; cerebellar volume n = 8, 4, 3, 9, 10). Each dot represents an individual zebrafish. Data represents raw data for five biological replicates plotted with the mean ± SD predicted by the mixed model statistical test. Scale bar = 100 µm. n.s., non-significant; Rep, replicate.

Expression Data

Gene:	EGFP
Fish:	knu3Tg (TU) uba5^mnu11/mnu11; knu3Tg (TU)
Anatomical Terms:	brain cerebellum
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	uba5^mnu11/mnu11; knu3Tg (TU)
Observed In:	brain cerebellum
Stage:	Day 6

Phenotype Detail

Acknowledgments

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